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Finally, adjusted indirect comparisons may not account for residual confounding because of unobserved differences between trials and, therefore, these findings cannot replace a direct headtohead trial, and conducting a trial to compare tirzepatide and semaglutide 2 mg would validate these findings

Avoid or limit NSAIDs (like ibuprofen) which can irritate the stomach

The field has sometimes been overshadowed by outlandish claims promising dramatic life extension, but researchers say that misses the point

[1] The medication carries a boxed warning regarding thyroid C-cell tumors observed in rodent studies and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

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